Beach Walks with Rox (This is a video podcast)
Classical 95.9 WCRI
Classical Music from Aspen Public Radio
Conversations with Mensa
Geek News Central Podcast
Great Pianists Podcasts from Magnatunes
It's a Purl, Man
Let's Knit Together (This is a video podcast)
Never Not Knitting
Ready Set Knit
Socks in the City
Stash & Burn
Sticks & String
WGBH Classical Performance
If you aren't a technophile, you will probably be happy to know that you don't need an iPod to listen to these. I recommend you get iTunes so that you can listen on your computer. Then check the podcasts in your iTunes Store and you will find all sorts of them, usually free.
Most of the links I have listed above will have a button for you to subscribe to their podcast with iTunes. Then these wonderful programs will be downloaded automatically into your computer and they will be there when you want to listen.
Give podcasts a try; I think you will be pleasantly surprised!